黑丝 做爱

Volume 2 Issue 9

封面解读

刘鹏

胡亚伟

Diffuse midline glioma (DMG)， H3K27-altered， is a lethal pediatric high-grade tumor， lacking effective treatment options， primarily depending on clinical trials. Epigenetic agent-based immunotherapy has shown promise， but the underlying mechanisms remain unclear. To address the scarcity of tumor samples， researchers utilize patient-derived tumor cells to explore DMG heterogeneity. The epigenetic characteristics of DMG include a loss of H3K27me3 and a gain of H3K27ac. To overcome the limitations of traditional techniques， we developed high-throughputin situtagged immunoprecipitation sequencing (HiTIP-seq) utilizing InSMART， enabling 100 parallel assays from just 100 cells on a single chip. Using this new method， we analyzed epigenetic alterations in 3D cell cultures derived from DMG patients， discovering that combinations of epigenetic agents (such as panobinostat and tazemetostat) can reprogram histone modifications and drive transcriptome changes， notably upregulatingWIF1. HiTIP-seq provides a new tool for DMG research， showcasing hope in the fight against this deadly disease， and may ultimately lead to effective treatment options in the future.

目 录

导 读

1. Recent advances in surgical management strategies for hepatocellular carcinoma - ScienceDirectScienceDirect

通信作家：周俭

HIGHLIGHTS

Due to different disease backgrounds， different surgical treatments for hepatocellular carcinoma (HCC) have been developed.

Enhanced visualization methods and artificial intelligence provide benefits to both surgical oncologists and HCC patients.

The emergence and evolution of new technologies have broken through the forbidden zone of HCC surgical treatment.

With the exploration of innovative clinical trials， the surgical management pattern of HCC may be continuously revolutionized.

援用：

Ding ZB， Shi YH， Chen JF， et al. Recent advances in surgical management strategies for hepatocellular carcinoma.hLife2024;2:439–453.

2. Discoidin domain receptor 1 as a potent therapeutic target in solid tumors

通信作家：金腾川

著述盘问了东谈主类跨膜卵白盘状卵白结构域受体1（DDR1）的结构、功能和病理特征，徐徐揭示了DDR1在实体瘤微环境中的作用，并提倡了其手脚潜在的调治靶点的可行性。

援用：

Bibi S， Zeng W， Zheng P， et al. Discoidin domain receptor 1 as a potent therapeutic target in solid tumors.hLife2024;2:454–466.

3. Surpassing the natural limits of serological diagnostic tests

通信作家：D. William Provance Jr.

援用：

Provance DW Jr， da Matta Durans A， Lechuga GC， et al. Surpassing the natural limits of serological diagnostic tests.hLife2024;2:467–470.

4. HiTIP-seq profiles epigenomic reprogramming of patient-derived diffuse midline glioma stem cells to epigenetic therapy

通信作家：刘鹏、章薇、胡亚伟

该商量基于微阵列芯片开垦出一种高通量原位瑰丽免疫千里淀测序时刻（HiTIP-seq），不仅为饱胀性中线胶质瘤（Diffuse Midline Glioma， DMG）商量提供了新时刻，更为其调治新政策提供了科学依据。

援用：

Chen Z， Gao Q， Shang Y， et al. HiTIP-seq profiles epigenomic reprogramming of patient-derived diffuse midline glioma stem cells to epigenetic therapy.hLife2024;2:471–487.

5. Nasal mucosal secretory immunoglobulin A but not serum antibodies is resistant to Omicron evasion

通信作家：陈凌、李锋

援用：

Chen S， Zhang Z， Wang Q黑丝 做爱， et al. Nasal mucosal secretory immunoglobulin A but not serum antibodies is resistant to Omicron evasion.hLife2024;2:488–491.